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Megadoses of up to 2,000 mcg are considered safe in treating a B12 deficiency, but its best to avoid excessive amounts of any vitamins, especially when not needed

It is engineered with two structural modifications relative to the 70-residue native protein: a substitution of arginine for glutamic acid at the third position and a 13-amino-acid extension at the N-terminus, giving a total length of 83 amino acids

Clinical Efficacy Observation of Yu-Shen Recipe and Abelmoschus Manihot on Proteinuria Caused by Chronic Nephritis of Qi-Yin Deficiency and Damp-Heat Syndrome