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Low reduced and oxidized glutathione ratios (GSH/GSSG) are often found in dogs with various hepatopathies (i.e., necroinflammatory liver disorders, extrahepatic bile duct obstruction, copper toxicosis, chronic extrahepatic cholestasis, and chronic hepatitis), along with decreased values of antioxidant enzymes and total antioxidant capacity indexes [90,91,92,102,104]

Inadequate intake of these nutrients can impair ALP production and activity

Public Health England 4.Oldridge NB, Stump TE, Nothwehr FK, Clark DO (2001) Prevalence and outcomes of comorbid metabolic and cardiovascular conditions in middle- and older-age adults

The exercise plus CITleucine group ( n = 10) showed significant gains in body weight, BMI, total body mass, household and overall physical activity, and plasma phenylalanine levels compared with controls