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While clinical trials are considered the gold standard for internal validity of safety and efficacy, the persistence and adherence rates are typically higher than those observed in real-world clinical practice [30]

doi:10.2147/CCID.S68424 6

Substantial number of evidences proposes ROS to be a major contributor of dopaminergic neuronal loss in the PD brain

In trial participants with advanced melanoma, the combination of nivolumab and ipilimumab demonstrated sustained, better clinical outcomes in comparison to monotherapy [289]