does tirzepatide work better than semaglutide for weight loss vs Tirzepatide: Which GLP-1 Wins Loss? Semaglutide vs Tirzepatide: Which Is

Prolonged elevation of blood glucose, as well as related adverse metabolic features such as dyslipidemia and chronic inflammation, lead ultimately to a range of debilitating health issues such as, cardiovascular disease, peripheral neuropathy, diabetic ketoacidosis, diabetic retinopathy, and diabetic nephropathy

There are several reasons to explain this limited beneficial effect on HbA1c (and also on body weight)

This is also consistent with our recent work showing that different ITCs lead to various degree of growth inhibition depending on their side chain structure 74

doi: 10.2353/ajpath.2010.090682 89 RuggeriRMGiovinazzoSBarbalaceMCCristaniMAlibrandiAVicchioTMet al