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The N-terminal region of GLP-1 is considered critical for receptor activation, whereas the C-terminal region predominantly facilitates receptor binding

While scalp allodynia is indeed a form of allodynia (commonly seen with migraines), whole-body skin sensitivity is the pattern associated with semaglutide in the published literature

Alternatives GLP-1 receptor agonists, including semaglutide, work by mimicking the GLP-1 hormone, which naturally suppresses hunger

Furthermore, in adults with type 2 diabetes and peripheral artery disease, semaglutide 1 mg/week improved overall walking distance, pain-free walking distance, quality of life, and reduced need for rescue treatments [48]