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10.1016/j.cell.2016.05.041 Cell 93 KoloskiN

For example: Certain amino acids are more sensitive to oxidation Peptides containing Trp residues may need even more protection from light and oxygen Acidic peptides and basic peptides may exhibit different stability profiles depending on the storage conditions Amino acid sequence can influence secondary structures and overall molecular stability (Sigma-Aldrich, 2023b

For global health applications, room-temperature stability is particularly important: it enables distribution in tropical climates without the cold-chain infrastructure that limits access to injectable biologics in much of the developing world