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Renal-Impaired Individuals: Chronic kidney disease is a major risk factor for diabetes, and many antidiabetic drugs are either contraindicated or need dose modifications in patients with renal impairment

Preventive Medicine 27(2):184-188

UC and OCD are both associated with gut microbiome alterations (40) and it is possible that in the setting of longstanding OCD, the emergence of UC triggered an inflammatory cascade resulting in neuroinflammation, dramatic worsening of OCD, and a bidirectional feedback loop of gut-systemic-neuro inflammation which impaired insulin signaling and resulted in carbohydrate craving, progressive obesity, and central adiposity

43, # 11, p