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Timeline: when patients notice changes The first changes most patients report are sleep-related, typically improved sleep depth and morning energy levels, appearing within weeks two to three of the first cycle

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A 2021 study by Zerbinati and colleagues tested a serum with 30% 3-O-ethyl-l-ascorbic acid and 1% lactic acid significantly increased collagen production, reduced UVB-induced DNA damage, and decreased melanin on a reconstructed pigmented skin model