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New insights into calorie restriction induced bone loss

It would be interesting to metabolically test the hypothesis whether ferroptosis inducers heavily engaged the DMAPP-tRNASelCys-GPX4 branch response that would explain the higher sensitivity to RSL3 of cells expressing UBIAD1, being the metabolic mevalonate pathway of the cells fully rewired to synthetize CoQ 10 instead of GPX4

Melanoma cells arising from the immature melanocytes that have become arrested in the lamina propria of the oral mucosa proliferate, forming nodular aggregates in the lamina propria/submucosa with or without breaching the subepithelial basement membrane

Zmitek K, Amitek J, Hristov H, Butina MR, Kersmanc P, Pogacnik T