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In Phase 3 studies: Participants without diabetes taking orforglipron lost approximately 9% to 10% of body weight over roughly 36 to 40 weeks Participants with type 2 diabetes generally lost around 7% to 8% By comparison, Wegovy's landmark STEP trials reported approximately 14.9% average weight loss over 68 weeks

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At the same time, the percentage of DNA fragmentation of both organs returned to average value after DAPA administration with a significant reduction ( p 0.05) compared to T4 group (Fig

Glutathione, often termed the "master antioxidant," plays a pivotal role in protecting cells from oxidative damage, supporting the immune system, and aiding in the detoxification of harmful substances in the body