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The prevalence of anxiety and depression among patients is 37% and 42%, respectively, with obese individuals being more susceptible to negative emotional states [44]

Women of childbearing potential should use effective contraception while on treatment and discuss stopping the medication before planned conception

Structural determination and refinement Structural determination of reduced OsDHAR was performed by the molecular replacement method with the MOLREP program by using a homology model of OsDHAR generated by the SWISS-MODEL server 32 and the coordinates of human CLIC1 as the template structure 12

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