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doi: 10.1111/cas.14181 Summary Keywords breast cancer, ferroptosis, lipid, oxidative damage, tumor progression, immune therapy, therapy Citation Li J, He D, Li S, Xiao J and Zhu Z (2023) Ferroptosis: the emerging player in remodeling triple-negative breast cancer

Essential baseline investigations typically include: Lipid profile : Total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides to establish baseline values HbA1c or fasting glucose : To screen for diabetes or prediabetes Liver function tests : As baseline measurement, particularly if considering long-term treatment Thyroid function tests : To exclude thyroid disorders that may affect weight Blood pressure measurement : To assess overall cardiovascular risk Renal function : Particularly important for patients on multiple medications Pregnancy test : Where appropriate, before starting treatment Cardiovascular risk assessment using tools such as QRISK3 helps determine the overall 10-year risk of cardiovascular disease

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In contrast to metformin, sulfonylureas increase blood insulin concentration via stimulation of pancreatic beta cells