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The most common reasons include end-of-dose crashes with Adderall, inconsistent symptom coverage throughout the day, mood instability linked to sharper plasma peaks and troughs, and the ongoing Adderall shortage that began in 2022

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While tirzepatide has yet to demonstrate direct cardiovascular risk outcomes in patients without type 2 diabetes, tirzepatide-treated groups did demonstrate reductions in cardiometabolic variables resulting in a significantly lower 10-year predicted ASCVD risk in patients with overweight or obesity without type 2 diabetes in post hoc analysis of the SURMOUNT-1 trial [49]