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Noteworthy is its maternal inheritance with a multicopy nature

15 The gene for glutathione peroxidase-4 is expressed in most tissues, including the brain (Gene Expression Atlas, available at Although the GPX4 gene is highly polymorphic, a limited number of studies 16, 17, 18, 19 have been done to investigate genetic variations within the GPX4 gene that could potentially alter the function of the enzyme

TNF- is a key mediator in the signal transduction pathways linked to inflammatory diseases, along with other inflammatory mediators

While scientific and policy responses have traditionally focused on isolated strategies, there is an increasing need to adopt a holistic model that integrates knowledge from physiology, endocrinology, nutrition, immunology, genetics, epigenetics, and microbiome research, alongside socio-economic and environmental factors [141]