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These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis

genetic associations with other risk factors were obtained from summary statistics in the Neale Lab GWAS of the UK Biobank, controlling for age, age 2 , and 20 principal components (Additional file 1: Table S1)

However, many people experience noticeable changes within a relatively short timeframe

Practical strategies to reduce kidney stone risk include: Maintain excellent hydration : Aim to drink 2.5 to 3 litres of fluid daily , primarily water, with a goal of producing at least 22.5 litres of urine per day