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That's a reason to keep on top of your nutrition and strength-training while on these drugs, he writes, "especially for older people like me, who are [already] susceptible to muscle loss." There are people who should steer clear of GLP-1 drugs, Kessler notes, including those with a personal or familial history of certain thyroid and endocrine cancers, those with chronic kidney disease, pancreatitis, inflammatory bowel diseases, uncontrolled diarrhea or constipation or gastroparesis, or if you are pregnant

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Three years of operating data have demolished that view

47 Exendin-4 significantly increased amyloid protein (A)-induced reduction in mitochondrial function, integrity, respiratory control rate, and mitochondrial P/O ratio in all brain regions and decreased A-induced increase in the mitochondrial complex enzyme-I, IV, and V activities in all brain regions