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This triple-action mechanism distinguishes retatrutide from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 receptor agonist)

Although how exactly these drugs help in weight loss is not known, as GLP-1 agonists slow the movement of food traveling from the stomach to the small intestine, it makes people feel full quicker and for longer, and so, it is thought to boost weight loss because people tend to eat less as result of the medication

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