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To view a copy of this licence, visit About this article Cite this article Xiao, Y., Yan, X., Liu, Z

Excretion Pathways Limited data on combined excretion indicates: Primarily renal elimination of peptide fragments Hepatic metabolism contributes to overall clearance Copper recycling through normal physiological pathways No evidence of accumulation in chronic dosing studies (animal models) The relationship between rapid plasma clearance and prolonged biological effects represents a key area requiring further mechanistic investigation across all three components

Concentration variability Brand-name pens deliver a pre-measured dose