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On 8 January 2024, the UK regulator told The Pharmaceutical Journal : The MHRA review is still in progress, and we cannot provide specific timelines or results at this time. According to MHRA Yellow Card reporting scheme, there have been 28 reports of suicidal and self-injurious behaviour among patients taking semaglutide and 23 reports for patients taking liraglutide
Baltimore, MD: American Association for the Study of Liver Diseases
However, a 2023 trial in The Lancet reported Ozempic led to 15% body weight loss but caused muscle loss and reduced bone density in some patients (link)
While, down-regulation of the transporter directly confers resistance against the drug, via decreasing the intracellular platinum concentration (Kunii et al., 2015)
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