potential indications for glp-1 receptor agonists keep expanding Cardiovascular Protective Properties of Agonists: More than Just Diabetic and Weight Loss Drugs Frontiers | GLP-1 Receptor Agonists:

The landmark PANTHEON trial, a 1-year multicenter RCT in 1,006 Chinese COPD patients, found that high-dose NAC (600 mg twice daily) reduced the rate of acute exacerbations by 22% compared to placebo (1.16 vs 1.49 exacerbations per year, p=0.0011) (Zheng et al., Lancet Respir Med, 2014) [44]

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However, emerging evidence suggests that their benefits extended beyond glycaemic control, with pleiotropic effects on multiple organ systems, including significant anti-fibrotic effects