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To avoid a possible effect of food and water intake and physical activity, the meal plan and total daily fluid intake as well as physical activeness were kept constant during the study and the patients received a dietary advice with provided by a renal dietitian before the study commenced

Additionally, individual patient factorsincluding baseline gastric emptying rate, previous gastrointestinal conditions, concomitant medications, and genetic variations in drug metabolismcontribute to the considerable inter-patient variability observed in clinical practice

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