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Dapagliflozin Infections: Necrotizing fasciitis of the perineum (Fourniers Gangrene), urosepsis and pyelonephritis Metabolism and Nutrition Disorders: Ketoacidosis Renal and Urinary Disorders: Acute kidney injury Skin and Subcutaneous Tissue Disorders: Rash Metformin HCl Hepatobiliary Disorders: Cholestatic, hepatocellular, and mixed hepatocellular liver injury Warnings for Xigduo XR Included as part of the PRECAUTIONS section

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The initial prescription typically starts at the lowest available dose to allow physiologic adaptation