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Pese a la vida media corta en plasma, los efectos biolgicos posteriores persisten en el tejido durante mucho ms tiempo, lo que es coherente con una cascada de sealizacin en lugar de una actividad dosis-respuesta directa

The inhibitory effect of GLP-1 on glucagon secretion in vivo was observed only when the blood glucose level was equal to or higher than the fasting level, at higher blood glucose levels, the inhibition of glucagon gradually increased (Holst, 2007), and when the blood glucose concentration was less than 3.7 m mol/L, GLP-1 lost its effect on inhibiting glucagon secretion (Nauck et al., 2002)

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The level of expression of CerS1 was shown to be significantly elevated in mice fed a high-fat diet