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In an embryofetal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075, and 0.15 mg/kg twice weekly (1.0-, 5.2-, and 14.9-fold the MRHD) were administered throughout organogenesis, from Gestation Day 16 to 50

This treatment may be offered as an alternative to DMSO

In that matched cohort, GLP-1 receptor agonist use was associated with a lower hazard of all-cause mortality, with a reported hazard ratio of 0.09, and a lower hazard of recurrence-free survival events, with a hazard ratio of 0.33 in unadjusted analyses

Clin Gastroenterol Hepatol Palchuk MB, London JW, Perez-Rey D, Drebert ZJ, Winer-Jones JP,Thompson CN, Claerhout B (2023) A global federated real-world data and analytics platform for research