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Canadian Medical Association Journal 1999;161:1469

Clinical research suggested doses in the range of 1-10mcg per kilogram of body weight showed efficacy, though most protocols standardized around 4-6mcg/kg for practical application

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But clearly I think what the study showed was that this is a practice that's probably happening more often in Ontario than it should be happening." Silverstein, a recent graduate of medical school, remembered that little time was spent on the appropriate treatment of B12 deficiency