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Although the contribution of an excessive intake of methionine has not been clinically proven, folate deficiency (associated or not with the thermolabile mutation of MTHFR) and vitamin B 6 deficiency (perhaps associated with heterozygosity for CBS deficiency or with methionine excess) would be strongly involved in the incidence of cardiovascular disease associated with moderate hyperhomocysteinemia

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Each of the three peptides is produced by solid-phase peptide synthesis (SPPS) , a standard method for short-peptide synthesis that ensures accurate chain assembly and minimizes impurities