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Extracellular alanine, as an environmental nutrient, is also required during T-cell activation and memory T-cell restimulation (Ron-Harel et al., 2019)

This suggests that while contaminants do play a role in distinguishing between controls and autoimmune diseases, they are unlikely to be the sole risk factors

Caudatins anti-inflammatory effects target JNK/AP-1 and NF-B cascades, while neuroprotective effects with reduced A in an Alzheimers model occur due to PPAR/TFEB-driven autophagy

Notably, SQOR deficiency leads to reduced cellular ubiquinol (CoQ 10 H 2 ) levels and increased sensitivity to ferroptotic stress, positioning SQOR as another mitochondria-resident suppressor of ferroptosis