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Estimula ciertas MMP necesarias para la remodelacin fisiolgica de los tejidos daados, al mismo tiempo que inhibe la sobreactivacin de las MMP que contribuye a la degradacin crnica de la matriz drmica observada en el fotoenvejecimiento

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The antimetabolite nature of MTX and its inhibitory effect on many important metabolic enzymes prompted us to study the consequences of MTX treatment on cellular metabolism

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Notably, ACSL4-driven lipid peroxidation is significantly potentiated under GPX4 deficiency (Wang R

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