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Description

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As an inner mitochondrial membrane enzyme primarily involved in pyrimidine synthesis, DHODH reduces CoQ10 to the specific antioxidant molecule CoQH via the electron transport chain [72]

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[149] The few studies that have used equivalent (weight-adjusted) human therapeutic doses and oral administration show that these changes, if they occur, are relatively minor

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emollient adjuncts or reduced application frequency often mitigate this effect

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