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Genetic variations affecting peptide metabolism, transport, or target receptor function could inform dosing decisions and treatment selection

141 They remain in the body, interacting with GLP-1 receptors in various organs, which could lead to DDIs through mechanisms of action such as slowing gastric emptying, reducing fat mass and inflammation, and increasing glomerular filtration rate (GFR) and renal plasma flow, consequently altering the pharmacokinetics of the victim drug (Figure 3)

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En los ensayos clnicos, los adultos de 65 aos o ms que tomaban medicamentos GLP-1 tenan ms probabilidades de experimentar ciertos efectos secundarios que los de entre 18 y 64 aos