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Moreover, HIF-1 also plays an important role in the regulation of chondrocyte autophagy in OA (84, 90)

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Collectively, these findings suggest that the integration of non-pharmacological strategies, such as HBOT, with pharmacological treatments may serve to optimize the therapeutic outcomes while potentially minimizing the dosage of medication required

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For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101

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