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67 In line with a role of ATII in endothelial dysfunction and hypertension, numerous studies have now demonstrated that the therapy with angiotensin-converting enzyme inhibitors and AT-1 receptor blockers is associated with an improvements in endothelial responsiveness 68, 69, 70, 71, 72 (the existence of negative reports also needs to be acknowledged)

Cognitive decline, dementia, and Alzheimer's disease The occurrence of vitamin B 12 deficiency prevails in the elderly population and has been frequently associated with Alzheimer's disease (reviewed in 63, 64)

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Galileo's observations included the first direct measurement of Jupiter's atmosphere, as well as close-up views of its moons, revealing their complex geology