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There was an increased number of thyroid cancers in the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) clinical trial evaluating liraglutide versus placebo, but the risk did not reach statistical significance (hazard ratio [HR] 1.66, 95% CI 0.406.95), as well as in a meta-analysis of 12 other clinical trials with liraglutide (odds ratio [OR] 1.54, 95% CI 0.406.02) (7,8)

INS-1 832/3 cells were kindly provided by Prof

Molecular Devices, CA, USA), where baseline was corrected and AUC was calculated

Prescribers seeking evidence-based guidance on the neuropsychiatric or affective side effect profile of GLP-1 receptor agonists, including semaglutide, should refer to the published regulatory safety communications from the FDA and EMA, the SUSTAIN and STEP trial data, and peer-reviewed pharmacovigilance literature examining anhedonia, mood changes, and related adverse events in this drug class