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McGee DL, Diverse Populations C

Elevated expression of AKR1C3 increases resistance of cancer cells to ionizing radiation via modulation of oxidative stress

Molecular modelling and mutagenesis studies indicate that agonist positive allosteric modulators target the same general region, but in a distinct sub-pocket at the interface between helices V and VI, which may facilitate the formation of an intracellular binding site that enhances G-protein coupling

This means slower results, inconsistent week-to-week responses, and the frustrating sense that the protocol is not working when the real problem is preparation