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3 Overview of ferroptosis Cell death is fundamental to organismal growth, development, senescence, and death, involving mechanisms such as apoptosis, necrotic apoptosis, autophagy, cellular pyroptosis, and necrosis, each with distinct characteristics (Moujalled et al., 2021)

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Oxidized Prdx2 forms an interchain disulfide, which is recycled by thioredoxin and thioredoxin reductase, and this requires reducing equivalents from NADPH