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In PCOS where insulin resistance is present in up to 80% of affected women regardless of body weight GLP-1 agonists have demonstrated measurable reductions in free testosterone, improved menstrual regularity, and significant metabolic benefit

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In women, virilization (development of male features) can occur and may be irreversible if the drug is not discontinued promptly.Other Side Effects: Other potential side effects include nausea, vomiting, insomnia, headache, rapid weight gain (swelling), and changes in skin color