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Ferroptosis and Cancer Genes RAS The RAS family of small GTPase, including HRAS, NRAS, and KRAS, is closely related to ferroptosis since the two most well-known ferroptosis inducers, erastin (eradicator of RAS and ST) and RSL3 (RAS-selective Lethal 3), are technically oncogenic RAS-selective lethal small molecules (Yagoda et al., 2007

6.2 Zinc muffling and buffering The short lifetime of zinc signals themselves implies that when cytosolic zinc concentration increases, cells are able to control it, i.e., they generate zinc signals of different amplitudes, minimize cytosolic zinc fluctuations, and eventually restore the equilibrium state of zinc concentration

e-Pub 2013

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