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In the body, the brain consumes a lot of energy, around 20% of the total energy produced (Watts 2018)

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For a POTS patient, simply changing posture can result in a skyrocketing heart rate, palpitations, tremors, and a profound sense of panic or anxietyoften referred to in the patient community as an "adrenaline dump." The body is trapped in a perpetual state of hyper-arousal, which is incredibly draining and contributes significantly to the profound fatigue seen in these conditions