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A dose of 8mg of the drug is recommended at the start of the prodrome, in combination with other abortive medications, such as triptans and anxiolytics

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4.3 Neurodegenerative diseases Since individuals with DS are prone to elevated levels of oxidative stress at an early age and consequent accumulation of ROS, which are cytotoxic byproducts of normal mitochondrial metabolism, there is an insufficient defense of endogenous antioxidants