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How It Works Testosterone therapy restores the androgenic hormonal environment necessary for muscle protein synthesis, energy, libido, and metabolic health

This reduces production of IL-1, IL-6, TNF-, and other cytokines driving chronic oral inflammation

There is generally no medically established shortcut for dramatically accelerating this process

A 2026 review published in Andrology consolidated the mechanistic evidence: kisspeptin modulation of GnRH pulsatility represents a testable biomarker pathway for differentiating PMOS from functional hypothalamic amenorrhea, and potentially for targeted therapeutic intervention