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These include: Blood Sugar Fluctuations Hypoglycemic episodes in some subjects Particularly relevant for subjects with existing metabolic conditions Requires careful monitoring and protocol adjustment Cardiovascular Responses Mild changes in heart rate and blood pressure Generally well-tolerated but requires monitoring May interact with existing cardiovascular medications Fatigue and Energy Changes Initial fatigue reported in 25-40% of subjects Often improves as metabolic adaptation occurs May be related to rapid metabolic changes Understanding these effects is crucial when designing research protocols

doi: 10.1371/journal.pone.0187434