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Identification of natural compound inhibitors for multidrug efflux pumps of Escherichia coli and Pseudomonas aeruginosa using in silico high-throughput virtual screening and in vitro validation

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Researchers using GHK-Cu in populations with impaired renal function should consider reducing dose frequency to every 72 hours instead of every 48 hours to avoid accumulation of copper, which is also renally excreted and can contribute to oxidative stress at excessive levels

Plant Cell 21:37493766 Le Martret B, Poage M, Shiel K, Nugent GD, Dix PJ (2011) Tobacco chloroplast transformants expressing genes encoding dehydroascorbate reductase, glutathione reductase, and glutathione- S -transferase, exhibit altered anti-oxidant metabolism and improved abiotic stress tolerance