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L.et al (2017)

Common side effects Injection-site reactions: mild redness, tenderness, swelling, occasional bruising - usually resolve within hours Skin flushing / warmth - brief, related to vasodilation Transient fatigue in the first 12 weeks of intensive protocols Mild headache - usually dose-related Higher-dose theoretical concerns Copper accumulation - each 2 mg injection adds roughly 0.03 mg of elemental copper, trivial next to the 0.92.2 mg from a normal diet

The key practical takeaway is this: water is both necessary and destructive

Sensitivity analysis excluding this sample did not materially alter group separation, suggesting biological heterogeneity rather than analytical artifact