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Likewise, substantial interactions with the copper ions by catechol group (B-ring) and free 3-OH (hydroxyl) group on the unconjugated C-ring plays a key role in the strong tyrosinase inhibition

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Further actions are anti-apoptotic process (BAX/Bcl-2), neurodifferentiation (phosphorylated protein kinase: pAkt, microtubule-associated protein-2: MAP2, growth-associated protein-43: GAP43 and ATP/GTP binding protein-like 4: AGBL4) and neuronal glucose homeostasis (Glucose transporter 1, 3, 4: GLUT1, GLUT3 and GLUT4)

Lipids exposed by damaged myelin have been identified as activators of TREM2, underscoring its role in microglial responses to white matter injury (Poliani et al., 2015)