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In astrocytes within the cerebral cortex of AD patients and APP/PS1 double-transgenic AD mice, NOX4 levels of were found to be significantly increased, as were levels of MDA and 4-HNE

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In another study, an 84-week open-label trial with about 800 participants, people taking CagriSema had an average of 23% weight loss versus about 25 to 26% for tirzepatide (Zepbound) at the highest dose