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All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)

Reconstitution reference U100 units to draw for each common Retatrutide dose, by vial size, reconstituted with 2 mL of bacteriostatic water

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