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Another approach involves modifying Lactobacillus plantarum to produce native GLP-1, which was shown to improve metabolic parameters, reduce inflammation, and restore -cell function in HFD/STZ mouse models of T2DM ( Of particular note is the ability of GLP1R agonists to induce transdifferentiation of intestinal cells into insulin-secreting cells

This observation aligns well with the crucial ability of viruses to interact with host proteins (for example in the Potyviridae family), leading to the induction and support of virus infection in different hosts (Yang et al., 2021)

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Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases