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To accommodate the tumors growth, there is an upregulation in the expression of angiogenic factors like vascular endothelial growth factor (VEGF), leading to the abnormal proliferation and expansion of tumor vasculature, a hallmark of high-grade gliomas [145]

They are not medicines, are not for human or veterinary consumption, and nothing in this article should be read as describing their use.

GLP-1 receptor agonists, and tirzepatide in particular, represent a fundamentally different philosophy

Baseline (before starting GLP-1 or supplements): 25-hydroxyvitamin D (target: 30-50 ng/mL) Vitamin B12 (target: above 400 pg/mL) Serum iron, ferritin, and TIBC Serum magnesium Serum zinc Complete metabolic panel CBC (to check for anemia) Follow-up testing at 3 and 6 months: Repeat all baseline labs Add: body composition measurement (DEXA scan is gold standard) to track lean mass vs fat mass changes Assess supplement adherence and adjust doses based on results The cost of basic nutritional bloodwork is minimal compared to the cost of undiagnosed deficiencies