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OCT embedded brains were cut into 10 m sections, the sections were rinsed three times with PBS, blocked for 1 h in 8% bovine serum albumin (BSA) dissolved in 0.01 M phosphate buffer (PB) containing 0.5% Triton-X100

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Inflammation haptocorrin levels can increase due to granulocyte activation or as an acute phase response Decreased clearance: Renal failure decreased clearance of transcobalaminB12 complexes Mechanism: Most elevated B12 is not free or biologically active , but rather bound to haptocorrin , which has a long half-life and is increased in certain diseases

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