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Journal of Medicinal Chemistry 48, 141-151 Lankas, G
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Side effects are similar regardless of age: primarily gastrointestinal (nausea, constipation, diarrhea)
By modulating isoprenoid synthesis and protein prenylation (Rho/Rac), statins blunt pro-inflammatory signaling, reduce mitochondrial ROS in endothelium and vascular smooth muscle, and improve NO bioavailability
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